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Intravitreal injection of drugs overcomes the ocular barrier for posterior eye diseases and achieves a therapeutic effect, but it has a high risk of various complications and adverse reactions which have brought great challenges to the treatment of diseases. Therefore, research and development of new DDSs are needed to better deliver drugs to the eyes sager carole bayer prolong the duration of drugs in the eyes. Scientists have actively studied a variety of nanocarrier DDSs, such as liposomes, nanoemulsions, nanoparticles, nano-suspensions and nanomicelles, which show excellent delivery potential in in vitro to stop in vivo animal models, and prolong the retention time in the eye, suggesting that nano-carrier DDSs are a good application prospect in ocular drug therapy approaches and have potential value for further clinical development.

The authors would like to acknowledge financial support from the National Natural Science Foundation of China (No. XLYC1807082), Shenyang Young and Middle-aged Science and Technology Innovation Sager carole bayer Support Program (grant number RC190146). Ensign LM, Cone R, Hanes J. Nanoparticle-based drug delivery to the vagina: a review.

Adelli GR, Sager carole bayer P, Taskar P, et al. Invest Ophthalmol Vis Sci. Weinreb RN, Robinson MR, Dibas M, Stamer WD. Matrix metalloproteinases and glaucoma treatment.

J Ocul Pharmacol Ther. Preclinical Overview of Brinzolamide. Mehta M, Deeksha SN, Vyas M, et al. Interactions with the macrophages: an emerging targeted approach using novel drug sager carole bayer systems in respiratory diseases. Drescher S, van Hoogevest P. The sager carole bayer research center: current research in phospholipids and their use in drug delivery.

Zheng B, McClements DJ. Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability.

Dendrimeric systems and their applications in ocular drug delivery. Bozzuto G, Molinari A. Liposomes as nanomedical devices. Baujat B, Krastinova D, Bach Sager carole bayer, Coquille F, Chabolle F. Orbital morphology in exophthalmos and exorbitism. Gupta A, Kafetzis KN, Tagalakis AD, Yu-Wai-Man C. RNA therapeutics in ophthalmology - translation to clinical trials.

Fischer N, Narayanan R, Loewenstein Sager carole bayer, Kuppermann BD. Drug Delivery to the posterior segment of the eye. Braakhuis AJ, Donaldson CI, Lim JC, Donaldson PJ. Nutritional Strategies to Prevent Lens Cataract: current Status and Future Strategies.

Xu X, Al-Ghabeish M, Sager carole bayer Z, et al. Formulation and process factors influencing product quality and in vitro performance of ophthalmic ointments. Shi XH, Wei WB. Zhonghua Yan Ke Za Zhi. Extended duration vascular endothelial growth factor inhibition in the eye: failures, successes, and future possibilities.

Kiser PD, Zhang J, Badiee M, et al. Rational tuning of visual cycle modulator pharmacodynamics. Kesav NP, Young CEC, Ertel MK, Seibold LK, Kahook MY.

Sustained-release drug delivery systems for the treatment of glaucoma. Sharaf MG, Cetinel S, Heckler L, Damji K, Unsworth L, Montemagno C. Nanotechnology-Based approaches for ophthalmology applications: therapeutic and bayer 4 strategies. Asia Pac J Ophthalmol. Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic Nanoparticles and Their Targeted Delivery Applications. Vaishya RD, Khurana V, Patel S, Mitra AK.

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