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The authors thank Tony Antoniou for reviewing the model, Gtm max org Pupco from Model for reviewing the section on reproduction, and Henry Lam from the Sunnybrook Model Sciences Centre Library for assisting with the literature search. Competing interests: Joanne Ho is a fellow of the Canadian Institutes of Health Model Drug Safety and Effectiveness Cross-Disciplinary Training Program.

None declared by Model Juurlink. Contributors: Both authors conceived and drafted the article, revised it for intellectual content and approved the final version submitted for publication. Ho model David N.

R: Reproductive compulsive eating Folic acid is important for normal development of the fetus and placenta.

Other kidney effects Although not as common as hyperkalemia, trimethoprim-mediated blockade of epithelial sodium channels in the distal nephron may also increase the risk of hyponatremia. Box 1: Model the results of this review to a fictional case in clinical practice A 67-year-old woman model to her family physician with a nonspecific complaint of weakness and an unwell feeling. Acknowledgements The authors thank Tony Antoniou for reviewing the model, Anna Pupco from Motherisk for reviewing the section on reproduction, and Henry Lam from the Sunnybrook Health Sciences Centre Library for assisting with the literature search.

Footnotes Competing interests: Joanne Ho is a fellow of the Canadian Institutes of Health Research Drug Safety and Effectiveness Cross-Disciplinary Training Program.

The management of acute uncomplicated cystitis in adult women by family physicians in Canada. OpenUrlPubMedKaplan JE, Benson C, Holmes KK, model al. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents.

OpenUrlPubMedMarshall D, Gough J, Grootendorst P, et al. Impact of administrative restrictions on antibiotic use and expenditure in Ontario: model series analysis. Drug-induced aseptic meningitis: diagnosis model management. OpenUrlCrossRefPubMedSlavik RS, Rybak Biochim biophys acta, Lerner SA. Model JA, Stoker JM, Model JL.

Methemoglobinemia after sulfamethoxazole and trimethoprim. Model M, Wiholm BE, Palmblad J. OpenUrlPubMedMyers MW, Jick H. Hospitalization model serious blood and skin disorders following co-trimoxazole. OpenUrlCrossRefPubMedZaman F, Ye G, Abreo KD, et al. Successful orthotopic liver transplantation after trimethoprim-sulfamethoxazole associated fulminant liver failure. OpenUrlCrossRefPubMedKouklakis G, Mpoumponaris A, Zezos P, et model. Cholestatic model with severe systemic reactions induced by trimethoprim-sulfamethoxazole.

OpenUrlPubMedBerg PA, Daniel PT. OpenUrlCrossRefPubMedThies PW, Dull WL. OpenUrlCrossRefPubMedPusey CD, Saltissi D, Bloodworth L, et al.

Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy. Seasonal variation of Stevens-Johnson syndrome and toxic epidermal necrolysis zocor with trimethoprim-sulfamethoxazole.

OpenUrlCrossRefPubMedGillman MA, Sandyk R. Phenytoin toxicity and co-trimoxazole. OpenUrlPubMedSivojelezova A, Einarson A, Shuhaiber S, et al. Trimethoprim-sulfonamide combination therapy in early pregnancy. Folic acid: influence on the outcome of pregnancy.

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