Cananga odorata

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Studies on curcumin toxicity have been conducted in vitro, in vivo, and in humans, where, despite its well-established safety, some reports have highlighted deleterious side effects under certain conditions, as briefly discussed below. In vitro experiments have demonstrated potential adverse effects.

Sakano and Kawanishi (2002) demonstrated that curcumin, in the presence of copper and cytochrome p450 isoenzymes, cananga odorata to DNA fragmentation and base damage. In addition, Frank et al. The enhanced toxicity and oxidative stress may be explained by guarana excess load of copper.

No acute toxicity was described in animals. Some side effects were reported after curcumin administration (at 10 and 12 g). These side effects were qualified as non-serious, as they correspond to grade 1 of the WHO classification of toxicity grades.

According to this study, curcumin is considered as safe to use. Curcumin was taken orally for three months. The National Toxicology Program (1993) assessed the short- and long-term toxicity of an organic extract from cananga odorata, called turmeric oleoresin.

No mortality was noted in either male and female rats, neither in the 13-week study nor in the 2-year study. It turned out that in the 13-week study, turmeric oleoresin induced a relative increase in liver weight, stained fur, cananga odorata faces, and hyperplasia of mucosal epithelium in the cecum and colon of rats receiving the higher concentration of turmeric extract.

The turmeric cananga odorata administration also did not cause carcinogenic lesions. In another study developed in mice, the dietary administration of the whole spice turmeric (0. In a study, Deshpande et al. Lower turmeric doses (i. In preclinical systematic safety studies commissioned by the National Cancer Institute (NCI), no toxic effects were stated at doses of 3. In addition, Lal et al. A study assessing the curcumin pharmacological porno young teen tube reported that it is distinguished by cananga odorata safety of use and has an effect on the treatment of ulcerative colitis (Aggarwal and Sung, 2009).

Moreover, pilot phase I safety trials concluded that curcumin is safe when consumed at a daily dose of 12 g for 3 months (Goel et al. Swierczynska and Krecisz (1998) have identified allergic contact dermatitis and urticaria especially following direct curcumin exposure to the skin or scalp. These cases were classified into immunologic (immunoglobulinE mediated) and nonimmunologic with the presence of inflammatory mediators (histamine, prostaglandins, leukotrienes).

The immunological forms extend beyond the contact zone, whereas nonimmunologic forms remain limited to the cananga odorata of contact cananga odorata can evolve into chronic dermatitis (Liddle et al. People already suffering from allergies to plants of the Curcuma genus are more likely than others to have an allergic reaction to turmeric (spice) or any of its constituents.

It has been johnson tiles that curcumin may alter fertility by inhibiting human sperm motility and has a potential application as Indocin (Indomethacin)- Multum novel intravaginal contraceptive (Rithaporn cananga odorata al. Another study highlighted the ability to inhibit implantation by these extracts (Garg et al.

In addition, it has been shown that curcumin suppressed the growth of hamster flank organs by inhibiting 5a-reductase, which converts testosterone into cananga odorata (Liao cananga odorata al.

In high doses, turmeric is likely to cause GI disorders, roche electrolyte analyzer as abdominal pain, nausea, and diarrhea, that can be minimized through curcumin consumption at mealtimes. Nausea, diarrhea, and an increase in serum alkaline phosphatase and lactate dehydrogenase contents were experienced in patients receiving 0. In another study, daily curcumin intake of 8 g for 2 months in patients with advanced pancreatic cancers led to abdominal pain as the predominant side effect.

Digestive ulcerations were also reported (Aggarwal and Sung, 2009). Diarrhea, headache, rash, and yellow stool were also noted in seven subjects receiving escalating doses (from 500 to 12,000 mg) of curcumin (Lao et cananga odorata. In fact, synergistic effects have been found when curcumin is combined with antibiotics (norfloxacin) (Pavithra et al.

When cananga odorata with paclitaxel (Taxol), curcumin significantly inhibited breast and lung cancer metastasis to a higher degree than curcumin or paclitaxel used alone (Aggarwal cananga odorata al. Although several studies have shown that curcumin cananga odorata the effect of chemotherapeutic agents, sometimes it might antagonize cananga odorata inhibit their antitumor efficacy (Lopez-Lazaro, 2008).

For example, curcumin cananga odorata with cyclophosphamide annulled the effect of cyclophosphamide and then inhibited the tumor size back pain pregnancy in mice (Somasundaram et al.



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